DINAMICS is co-funded by the European Commission as an Integrated Project (IP) under the 6th Framework Programme.
DINAMICS aims to promote the uptake of nanotechnological approaches by developing an integrated costeffective nanobiological sensor for detection of bioterrorism and environmental assays. The prime deliverable is an exploitable lab-on-a-chip device for detection of pathogens in water using on-the-spot recognition and detection based on the nanotechnological assembly of unlabelled DNA. DINAMICS will integrate DNA hybridisation sensors with microfluidics and signal conditioning/processing both on silicon and polymer substrates avoiding the use of external apparatus for fluid handling, electrical signal generation and processing, based on DNA hybridisation.
A sensory breakthrough will be achieved through two complementary technological solutions: Measurements based on electrical (capacitive) signals. If hybridisation occurs between target and probe the detected change can be functionalised. Detection through UV light absorption. Based on the recognition of different UV absorptions induced by DNA hybridisation. The development of a system where each sensing site in the microarray contains a UV microfabricated sensor is a goal of the project. After DNA hybridisation the whole array is illuminated with UV light and the absorption of each site is measured by the sensor.
The project will culminate in an integrated multi-technology product that will be high-tech, low-cost and time-efficient sensing device applicable for use in the water industry via the co-ordination of nano- and biotechnologies with new sensory science to deliver a product that will lead to major changes in the way the testing and diagnostics of harmful substances is done. Both methodologies will ensure an additional and reliable source of cost reduction through a drastic shortening of the sensing pipeline and without the need to transfer the samples to an analytical laboratory.
The IP Consortium includes major stakeholders from the relevant branches, end users and production system suppliers, ICT providers, SME and RTD performers, including Academic and Research Institutes. Lambda GmbH acts as the IP Coordinator, supported by Steinbeis-Europa-Zentrum in Karlsruhe.
The objective of the DINAMICS project is to use these technologies to develop an integrated and cost-effective nanobiological sensor for detection of bioterrorism and environmental assays. The
project’s prime deliverables will be exploitable prototype handheld and continuous monitoring devices for the detection of harmful substances in the water supply network. This will radically improve upon existing technologies, as it will deliver a fast, reliable and quantifiable on-the-spot recognition and detection mechanism based on the nanotechnological assembly of “unlabelled” DNA and its subsequent
DINAMICS project goals
1. Identify current and anticipated end-user requirements for DNA-based detectors for the identification of specific biohazards in the context of “first response” diagnostics and continuous monitoring
2. Develop sensor technology that will provide required sensitivity and speed of response whilst compatible with integration into a low-cost, high-volume lab-on-a-chip platform
3. Demonstrate the viability of the technology developed by producing prototype devices to meet specific end-user requirement specifications